Our research aims to understand the fundamental mechanisms underlying aging and to develop therapeutics and interventions that treat age-related diseases.

 

Funding

 

National Institute on Aging (NIA), National Institutes of Health (NIH)

Department of Defense, CDMRP, USAMRMC

American Federation for Aging Research (AFAR)
Glenn Foundation for Medical Research

USC Dornsife Population Research Center
The V Foundation
James H. Zumberge Research and Innovation Fund
Bakewell Foundation

Disclaimer: These studies are supported, in part, by grants from the National Institute on Aging. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute on Aging or the National Institutes of Health.

 

Publications 

(Publications by category | PDFs)

2019

Brandhorst S, Longo VD. Dietary Restrictions and Nutrition in the Prevention and Treatment of Cardiovascular Disease. Circ Res. 2019 Mar 15;124(6):952-965. doi: 10.1161/CIRCRESAHA.118.313352.PMID: 30870119

Rangan P, Choi I, Wei M, Navarrete G, Guen E, Brandhorst S, Enyati N, Pasia G, Maesincee D, Ocon V, Abdulridha M, Longo VD. Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology. Cell Rep. 2019;26(10):2704-19 e6. doi: 10.1016/j.celrep.2019.02.019. PubMed PMID: 30840892.

2018

Nencioni A, Caffa I, Cortellino S, Longo VD. Fasting and cancer: molecular mechanisms and clinical application. Nat Rev Cancer. 2018 Nov;18(11):707-719. doi: 10.1038/s41568-018-0061-0. Review. PMID: 30327499

Nencioni A, Caffa I, Cortellino S, Longo VD. Reply to 'Fasting in oncology: a word of caution'. Nat Rev Cancer. 2019 Jan 16. doi: 10.1038/s41568-018-0100-x. [Epub ahead of print] No abstract available. PMID: 30651605

Guidi N, Longo VD. Periodic fasting starves cisplatin-resistant cancers to death. EMBO J. 2018;37(14). doi: 10.15252/embj.201899815. PubMed PMID: 29875131; PMCID: PMC6043846.

Buono R, Longo VD. Starvation, Stress Resistance, and Cancer. Trends in endocrinology and metabolism: TEM. 2018;29(4):271-80. doi: 10.1016/j.tem.2018.01.008. PubMed PMID: 29463451.

2017

Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR. Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab. 2017;25(6):1320-33 e5. PubMed PMID: 28591635.

 

Brandhorst S, Harputlugil E, Mitchell JR, Longo VD. Protective effects of short-term dietary restriction in surgical stress and chemotherapy. Ageing research reviews. 2017. PubMed PMID: 28216454.

Di Biase S, Shim HS, Kim KH, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Mirzaei H, Lee C, Longo VD. Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. PLoS Biol. 2017;15(3):e2001951. doi: 10.1371/journal.pbio.2001951. PubMed PMID: 28358805.

Lee AS, Brandhorst S, Rangel DF, Navarrete G, Cohen P, Longo VD, Chen J, Groshen S, Morgan TE, Dubeau L. Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Sci Rep. 2017;7:40919. doi: 10.1038/srep40919. PubMed PMID: 28145503; PMCID: PMC5286507.

Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, Cohen P, Sneddon JB, Perin L, Longo VD. Fasting-Mimicking Diet Promotes Ngn3-Driven beta-Cell Regeneration to Reverse Diabetes. Cell. 2017;168(5):775-88 e12. doi: 10.1016/j.cell.2017.01.040. PubMed PMID: 28235195.

Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo VD. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med. 2017;9(377). doi: 10.1126/scitranslmed.aai8700. PubMed PMID: 28202779.

Nashiro K, Guevara-Aguirre J, Braskie MN, Hafzalla GW, Velasco R, Balasubramian P, Wei M, Thompson PM, Mather M, Nelson MD, Guevara A, Teran E, Longo VD. Brain structure and function associated with younger adults in growth hormone receptor deficient humans. J Neurosci. 2017. doi: 10.1523/JNEUROSCI.1929-16.2016. PubMed PMID: 28073935.

Choi IY, Lee C, Longo VD. Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence. Molecular and cellular endocrinology. 2017. doi: 10.1016/j.mce.2017.01.042. PubMed PMID: 28137612.

2016

 

Song M, Fung TT, Hu FB, Willett WC, Longo VD, Chan AT, Giovannucci EL. Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality. JAMA Intern Med. 2016;176(10):1453-63. doi: 10.1001/jamainternmed.2016.4182. PubMed PMID: 27479196; PMCID: PMC5048552.​

Brandhorst S, Longo VD. Fasting and Caloric Restriction in Cancer Prevention and Treatment. Recent Results Cancer Res. 2016;207:241-66. doi: 10.1007/978-3-319-42118-6_12. PubMed PMID: 27557543.​

Longo VD, Cortellino S. Enhancing Stem Cell Transplantation with "Nutri-technology". Cell stem cell. 2016;19(6):681-2. doi: 10.1016/j.stem.2016.11.015. PubMed PMID: 27912088.

Mattson MP, Longo VD, Harvie M. Impact of intermittent fasting on health and disease processes. Ageing research reviews. 2016. doi: 10.1016/j.arr.2016.10.005. PubMed PMID: 27810402.

 

Longo VD, Panda S. Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. Cell Metab. 2016;23(6):1048-59. doi: 10.1016/j.cmet.2016.06.001. PubMed PMID: 27304506.

Di Biase S, Longo VD. Fasting-induced differential stress sensitization in cancer treatment. Mol Cell Oncol. 2016;3(3):e1117701. doi: 10.1080/23723556.2015.1117701. PubMed PMID: 27314084; PMCID: PMC4909408.

Mirzaei H, Di Biase S, Longo VD. Dietary Interventions, Cardiovascular Aging, and Disease: Animal Models and Human Studies. Circ Res. 2016;118(10):1612-25. doi: 10.1161/CIRCRESAHA.116.307473. PubMed PMID: 27174953.

 

Di Biase S, Lee C, Brandhorst S, Manes B, Buono R, Cheng CW, Cacciottolo M, Martin-Montalvo A, de Cabo R, Wei M, Morgan TE, Longo VD. Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity. Cancer cell. 2016;30(1):136-46. doi: 10.1016/j.ccell.2016.06.005. PubMed PMID: 27411588.

Choi IY, Piccio L, Childress P, Bollman B, Ghosh A, Brandhorst S, Suarez J, Michalsen A, Cross AH, Morgan TE, Wei M, Paul F, Bock M, Longo VD. A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell reports. 2016;15(10):2136-46. doi: 10.1016/j.celrep.2016.05.009. PubMed PMID: 27239035; PMCID: PMC4899145.

 

Dorff TB, Groshen S, Garcia A, Shah M, Tsao-Wei D, Pham H, Cheng CW, Brandhorst S, Cohen P, Wei M, Longo V, Quinn DI. Safety and feasibility of fasting in combination with platinum-based chemotherapy. BMC Cancer. 2016;16(1):360. doi: 10.1186/s12885-016-2370-6. PubMed PMID: 27282289; PMCID: PMC4901417.

Mirzaei H, Raynes R, Longo VD. The conserved role of protein restriction in aging and disease. Curr Opin Clin Nutr Metab Care. 2016;19(1):74-9. doi: 10.1097/MCO.0000000000000239. PubMed PMID: 26560522; PMCID: PMC4807119.

 

Balasubramanian P, Longo VD. Growth factors, aging and age-related diseases. Growth Horm IGF Res. 2016;28:66-8. doi: 10.1016/j.ghir.2016.01.001. PubMed PMID: 26883276.

 

2015

Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015;22(1):86-99. doi: 10.1016/j.cmet.2015.05.012. PubMed PMID: 26094889; PMCID: PMC4509734.

 

Shim HS, Wei M, Brandhorst S, Longo VD. Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. Cancer Res. 2015;75(6):1056-67. doi: 10.1158/0008-5472.CAN-14-2249. PubMed PMID: 25614517; PMCID: 4359966.

 

Shim HS, Longo VD. A protein restriction-dependent sulfur code for longevity. Cell. 2015;160(1-2):15-7. doi: 10.1016/j.cell.2014.12.027. PubMed PMID: 25594171.

 

Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 2015. doi: 10.1111/acel.12338. PubMed PMID: 25902704.

 

Guevara-Aguirre J, Rosenbloom AL, Balasubramanian P, Teran E, Guevara-Aguirre M, Guevara C, Procel P, Alfaras I, De Cabo R, Di Biase S, Narvaez L, Saavedra J, Longo VD. GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity. J Clin Endocrinol Metab. 2015;100(7):2589-96. doi: 10.1210/jc.2015-1678. PubMed PMID: 25985182.

 

Caffa I, D'Agostino V, Damonte P, Soncini D, Cea M, Monacelli F, Odetti P, Ballestrero A, Provenzani A, Longo VD, Nencioni A. Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition. Oncotarget. 2015;6(14):11820-32. PubMed PMID: 25909220.

 

Bianchi G, Martella R, Ravera S, Marini C, Capitanio S, Orengo A, Emionite L, Lavarello C, Amaro A, Petretto A, Pfeffer U, Sambuceti G, Pistoia V, Raffaghello L, Longo VD. Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models. Oncotarget. 2015;6(14):11806-19. PubMed PMID: 25909219.

Hirschey MD, DeBerardinis RJ, Diehl AM, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, Michelotti G, Muralidhar V, Murphy MP, Pedersen PL, Poore B, Raffaghello L, Rathmell JC, Sivanand S, Vander Heiden MG, Wellen KE, Target Validation T. Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol. 2015;35 Suppl:S129-50. doi: 10.1016/j.semcancer.2015.10.002. PubMed PMID: 26454069; PMCID: PMC4656121.

 

Block KI, et al. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol. 2015;35 Suppl:S276-304. doi: 10.1016/j.semcancer.2015.09.007. PubMed PMID: 26590477; PMCID: PMC4819002.

 

2014

Mirzaei H, Suarez JA, Longo VD. Protein and amino acid restriction, aging and disease: from yeast to humans. Trends Endocrinol Metab. 2014. doi: 10.1016/j.tem.2014.07.002. PubMed PMID: 25153840.

 

Mirzaei H, Longo VD. Acetyl-CoA synthetase is a conserved regulator of autophagy and life span. Cell Metab. 2014;19(4):555-7. doi: 10.1016/j.cmet.2014.03.021. PubMed PMID: 24703691; PubMed Central PMCID: PMC4036695.

 

Mirisola MG, Taormina G, Fabrizio P, Wei M, Hu J, Longo VD. Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging. PLoS Genet. 2014;10(2):e1004113. doi: 10.1371/journal.pgen.1004113. PubMed PMID: 24516402; PubMed Central PMCID: PMC3916422.

 

Mercken EM, Hu J, Krzysik-Walker S, Wei M, Li Y, McBurney MW, de Cabo R, Longo VD. SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice. Aging Cell. 2014;13(1):193-6. doi: 10.1111/acel.12151. PubMed PMID: 23941528; PubMed Central PMCID: PMC3907112.

 

Longo VD, Mattson MP. Fasting: molecular mechanisms and clinical applications. Cell Metab. 2014;19(2):181-92. doi: 10.1016/j.cmet.2013.12.008. PubMed PMID: 24440038; PubMed Central PMCID: PMC3946160.

 

Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab. 2014;19(3):407-17. doi: 10.1016/j.cmet.2014.02.006. PubMed PMID: 24606898; PubMed Central PMCID: PMC3988204.

 

Hu J, Wei M, Mirzaei H, Madia F, Mirisola M, Amparo C, Chagoury S, Kennedy B, Longo VD. Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity. Aging Cell. 2014;13(3):457-67. doi: 10.1111/acel.12202. PubMed PMID: 24649827; PubMed Central PMCID: PMC4032597.

 

Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS, Da Sacco S, Mirisola M, Quinn DI, Dorff TB, Kopchick JJ, Longo VD. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell. 2014;14(6):810-23. doi: 10.1016/j.stem.2014.04.014. PubMed PMID: 24905167; PubMed Central PMCID: PMC4102383.

 

2013

Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, Cohen P, Fontana L, Longo VD. Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell. 2013;12(2):257-68. doi: 10.1111/acel.12049. PubMed PMID: 23362919; PubMed Central PMCID: PMC3982836.

 

Nencioni A, Cea M, Montecucco F, Longo VD, Patrone F, Carella AM, Holyoake TL, Helgason GV. Autophagy in blood cancers: biological role and therapeutic implications. Haematologica. 2013;98(9):1335-43. doi: 10.3324/haematol.2012.079061. PubMed PMID: 24006406; PubMed Central PMCID: PMC3762088.

 

Mirisola MG, Longo VD. A radical signal activates the epigenetic regulation of longevity. Cell Metab. 2013;17(6):812-3. doi: 10.1016/j.cmet.2013.05.015. PubMed PMID: 23747240.

 

Hu J, Wei M, Mirisola MG, Longo VD. Assessing chronological aging in Saccharomyces cerevisiae. Methods Mol Biol. 2013;965:463-72. doi: 10.1007/978-1-62703-239-1_30. PubMed PMID: 23296677; PubMed Central PMCID: PMC4041521.

Gonidakis S, Longo VD. Assessing chronological aging in bacteria. Methods Mol Biol. 2013;965:421-37. doi: 10.1007/978-1-62703-239-1_28. PubMed PMID: 23296675.

 

Fontana L, Adelaiye RM, Rastelli AL, Miles KM, Ciamporcero E, Longo VD, Nguyen H, Vessella R, Pili R. Dietary protein restriction inhibits tumor growth in human xenograft models. Oncotarget. 2013;4(12):2451-61. PubMed PMID: 24353195.

 

Brandhorst S, Wei M, Hwang S, Morgan TE, Longo VD. Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression. Exp Gerontol. 2013;48(10):1120-8. doi: 10.1016/j.exger.2013.02.016. PubMed PMID: 23454633; PubMed Central PMCID: PMC3762887.

 

Bartke A, Sun LY, Longo V. Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiol Rev. 2013;93(2):571-98. doi: 10.1152/physrev.00006.2012. PubMed PMID: 23589828; PubMed Central PMCID: PMC3768106.

Balasubramanian P, Longo VD. Aging, nutrient signaling, hematopoietic senescence, and cancer. Crit Rev Oncog. 2013;18(6):559-71. PubMed PMID: 24579735; PubMed Central PMCID: PMC3959897.

 

2012

Safdie F, Brandhorst S, Wei M, Wang W, Lee C, Hwang S, Conti PS, Chen TC, Longo VD. Fasting enhances the response of glioma to chemo- and radiotherapy. PLoS One. 2012;7(9):e44603. doi: 10.1371/journal.pone.0044603. PubMed PMID: 22984531; PubMed Central PMCID: PMC3439413.

 

Pfaffenbach KT, Pong M, Morgan TE, Wang H, Ott K, Zhou B, Longo VD, Lee AS. GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling. J Cell Physiol. 2012;227(12):3803-11. doi: 10.1002/jcp.24090. PubMed PMID: 22422508; PubMed Central PMCID: PMC3421054.

 

Mirisola MG, Longo VD. Acetic acid and acidification accelerate chronological and replicative aging in yeast. Cell Cycle. 2012;11(19):3532-3. doi: 10.4161/cc.22042. PubMed PMID: 22951542; PubMed Central PMCID: PMC3478300.

 

Longo VD, Shadel GS, Kaeberlein M, Kennedy B. Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab. 2012;16(1):18-31. doi: 10.1016/j.cmet.2012.06.002. PubMed PMID: 22768836; PubMed Central PMCID: PMC3392685.

 

Longo VD, Fabrizio P. Chronological Aging in Saccharomyces cerevisiae. Subcell Biochem. 2012;57:101-21. doi: 10.1007/978-94-007-2561-4_5. PubMed PMID: 22094419.

 

Lee C, Raffaghello L, Longo VD. Starvation, detoxification, and multidrug resistance in cancer therapy. Drug Resist Updat. 2012;15(1-2):114-22. doi: 10.1016/j.drup.2012.01.004. PubMed PMID: 22391012; PubMed Central PMCID: PMC3573885.

 

Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Martin-Montalvo A, Pistoia V, Wei M, Hwang S, Merlino A, Emionite L, de Cabo R, Longo VD. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med. 2012;4(124):124ra27. doi: 10.1126/scitranslmed.3003293. PubMed PMID: 22323820; PubMed Central PMCID: PMC3608686.

 

Fontana L, Vinciguerra M, Longo VD. Growth factors, nutrient signaling, and cardiovascular aging. Circ Res. 2012;110(8):1139-50. doi: 10.1161/CIRCRESAHA.111.246470. PubMed PMID: 22499903; PubMed Central PMCID: PMC3376758.

 

2011

Wei M, Madia F, Longo VD. Studying age-dependent genomic instability using the S. cerevisiae chronological lifespan model. J Vis Exp. 2011(55). doi: 10.3791/3030. PubMed PMID: 21989366; PubMed Central PMCID: PMC3230202.

 

Sehati S, Clement MH, Martins J, Xu L, Longo VD, Valentine JS, Gralla EB. Metabolic alterations in yeast lacking copper-zinc superoxide dismutase. Free Radic Biol Med. 2011;50(11):1591-8. doi: 10.1016/j.freeradbiomed.2011.03.004. PubMed PMID: 21397007; PubMed Central PMCID: PMC3090513.

 

Mirisola MG, Longo VD. Conserved role of Ras-GEFs in promoting aging: from yeast to mice. Aging (Albany NY). 2011;3(4):340-3. PubMed PMID: 21732566; PubMed Central PMCID: PMC3117446.

 

Longo VD, Fontana L. Intermittent supplementation with rapamycin as a dietary restriction mimetic. Aging (Albany NY). 2011;3(11):1039-40. PubMed PMID: 22147496; PubMed Central PMCID: PMC3249447.

Lee C, Longo VD. Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. Oncogene. 2011;30(30):3305-16. doi: 10.1038/onc.2011.91. PubMed PMID: 21516129.

 

Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med. 2011;3(70):70ra13. doi: 10.1126/scitranslmed.3001845. PubMed PMID: 21325617; PubMed Central PMCID: PMC3357623.

 

Gonidakis S, Finkel SE, Longo VD. Lifespan extension and paraquat resistance in a ubiquinone-deficient Escherichia coli mutant depend on transcription factors ArcA and TdcA. Aging (Albany NY). 2011;3(3):291-303. PubMed PMID: 21464517; PubMed Central PMCID: PMC3091522.

2010

Wei M, Madia F, de Cabo R, Longo VD. Aging and Dietary Restriction: The Yeast Paradigm. In: Everitt AV, Rattan SIS, Le Couteur DG, de Cabo R, editors. Calorie Restriction, Aging and Longevity. New York: Springer; 2010.

Parrella E, Longo VD. Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. ScientificWorldJournal. 2010;10:161-77. doi: 10.1100/tsw.2010.8. PubMed PMID: 20098959.

Michan S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, Sinclair DA, Baudry M, de Cabo R, Longo VD. SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci. 2010;30(29):9695-707. doi: 10.1523/JNEUROSCI.0027-10.2010. PubMed PMID: 20660252; PMCID: 2921958.

Longo VD, Nislow C, Fabrizio P. Endosomal protein sorting and autophagy genes contribute to the regulation of yeast life span. Autophagy. 2010;6(8):1227-8. PubMed PMID: 20953148.

Longo VD, Fontana L. Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol Sci. 2010;31(2):89-98. doi: 10.1016/j.tips.2009.11.004. PubMed PMID: 20097433; PMCID: 2829867.

Lee C, Safdie FM, Raffaghello L, Wei M, Madia F, Parrella E, Hwang D, Cohen P, Bianchi G, Longo VD. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer research. 2010;70(4):1564-72. doi: 10.1158/0008-5472.CAN-09-3228. PubMed PMID: 20145127; PMCID: 2836202.

Gonidakis S, Finkel SE, Longo VD. Genome-wide screen identifies Escherichia coli TCA-cycle-related mutants with extended chronological lifespan dependent on acetate metabolism and the hypoxia-inducible transcription factor ArcA. Aging cell. 2010;9(5):868-81. doi: 10.1111/j.1474-9726.2010.00618.x. PubMed PMID: 20707865; PMCID: 2941539.

Gonidakis S, Finkel SE, Longo VD. E. coli hypoxia-inducible factor ArcA mediates lifespan extension in a lipoic acid synthase mutant by suppressing acetyl-CoA synthetase. Biol Chem. 2010;391(10):1139-47. doi: 10.1515/BC.2010.120. PubMed PMID: 20707605.

Ge H, Wei M, Fabrizio P, Hu J, Cheng C, Longo VD, Li LM. Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant. Nucleic Acids Res. 2010;38(1):143-58. doi: 10.1093/nar/gkp849. PubMed PMID: 19880387; PMCID: 2800218.

Fontana L, Partridge L, Longo VD. Extending healthy life span--from yeast to humans. Science. 2010;328(5976):321-6. doi: 10.1126/science.1172539. PubMed PMID: 20395504; PMCID: 3607354.

Finch CE, Morgan TE, Longo VD, de Magalhaes JP. Cell resilience in species life spans: a link to inflammation? Aging cell. 2010;9(4):519-26. doi: 10.1111/j.1474-9726.2010.00578.x. PubMed PMID: 20415721; PMCID: 2952360.

Fabrizio P, Hoon S, Shamalnasab M, Galbani A, Wei M, Giaever G, Nislow C, Longo VD. Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. PLoS Genet. 2010;6(7):e1001024. doi: 10.1371/journal.pgen.1001024. PubMed PMID: 20657825; PMCID: 2904796.