Autoimmune Diseases​
 
  1. Rangan P., Choi I., et al. Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology. Cell Rep. 2019;26(10):2704-19 e6. 

  2. Choi, I.Y., C. Lee, and V.D. Longo, Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence. Mol Cell Endocrinol, 2017. PDF

  3. Choi, I.Y., et al., A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Rep, 2016. 15(10): p. 2136-46. PDF

  4. Longo, V.D. and S. Cortellino, Enhancing Stem Cell Transplantation with "Nutri-technology". Cell Stem Cell, 2016. 19(6): p. 681-682. PDF

  5. Fasting transformed me after medicine failed; This free, simple therapy has changed my life. Could it be the panacea to transform the NHS? - The Times (Longdon) PDF

  6. Cheng, C.W., et al., Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell, 2014. 14(6): p. 810-23. PDF

 
 
Cancer
  1. Nencioni A, Caffa I, Cortellino S, Longo VD. Fasting and cancer: molecular mechanisms and clinical application. Nat Rev Cancer. 2018 Nov;18(11):707-719. doi: 10.1038/s41568-018-0061-0. Review. PMID: 30327499

  2. Guidi N, Longo VD. Periodic fasting starves cisplatin-resistant cancers to death. EMBO J. 2018;37(14). doi: 10.15252/embj.201899815. PubMed PMID: 29875131; PMCID: PMC6043846. PDF

  3. Buono R, Longo VD. Starvation, Stress Resistance, and Cancer. Trends in endocrinology and metabolism: TEM. 2018;29(4):271-80. doi: 10.1016/j.tem.2018.01.008. PubMed PMID: 29463451. PDF

  4. Wei, M., et al., Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med, 2017. 9(377). PDF

  5. Nashiro, K., et al., Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans. J Neurosci, 2017. 37(7): p. 1696-1707. PDF

  6. Lee, A.S., et al., Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Sci Rep, 2017. 7: p. 40919. PDF

  7. Hine, C., et al., Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab, 2017. 25(6): p. 1320-1333 e5. PDF

  8. Brandhorst, S., et al., Protective effects of short-term dietary restriction in surgical stress and chemotherapy. Ageing Res Rev, 2017. PDF

  9. Vernieri, C., et al., Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions. Cancer Discov, 2016. 6(12): p. 1315-1333. PDF

  10. Song, M., et al., Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality. JAMA Intern Med, 2016. 176(10): p. 1453-1463. PDF

  11. Mattson, M.P., V.D. Longo, and M. Harvie, Impact of intermittent fasting on health and disease processes. Ageing Res Rev, 2016. PDF

  12. Dorff, T.B., et al., Safety and feasibility of fasting in combination with platinum-based chemotherapy. BMC Cancer, 2016. 16(1): p. 360. PDF

  13. Di Biase, S. and V.D. Longo, Fasting-induced differential stress sensitization in cancer treatment. Mol Cell Oncol, 2016. 3(3): p. e1117701. PDF

  14. Di Biase, S., et al., Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity. Cancer Cell, 2016. 30(1): p. 136-46. PDF

  15. Brandhorst, S. and V.D. Longo, Fasting and Caloric Restriction in Cancer Prevention and Treatment. Recent Results Cancer Res, 2016. 207: p. 241-66. PDF

  16. Shim, H.S., et al., Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. Cancer Res, 2015. 75(6): p. 1056-67. PDF

  17. Hirschey, M.D., et al., Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol, 2015. 35 Suppl: p. S129-50. PDF

  18. Caffa, I., V.D. Longo, and A. Nencioni, Fasting plus tyrosine kinase inhibitors in cancer. Aging (Albany NY), 2015. 7(12): p. 1026-7. PDF

  19. Block, K.I., et al., Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol, 2015. 35 Suppl: p. S276-304. PDF

  20. Mattson, M.P., et al., Meal frequency and timing in health and disease. Proc Natl Acad Sci U S A, 2014. 111(47): p. 16647-53. PDF

  21. Longo, V.D. and M.P. Mattson, Fasting: molecular mechanisms and clinical applications. Cell Metab, 2014. 19(2): p. 181-92. PDF

  22. Levine, M.E., et al., Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab, 2014. 19(3): p. 407-17. PDF

  23. Cheng, C.W., et al., Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell, 2014. 14(6): p. 810-23. PDF

  24. Nencioni, A., et al., Autophagy in blood cancers: biological role and therapeutic implications. Haematologica, 2013. 98(9): p. 1335-43. PDF

  25. Brandhorst, S., et al., Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression. Exp Gerontol, 2013. 48(10): p. 1120-8. PDF

  26. Balasubramanian, P. and V.D. Longo, Aging, nutrient signaling, hematopoietic senescence, and cancer. Crit Rev Oncog, 2013. 18(6): p. 559-71. PDF

  27. Safdie, F., et al., Fasting enhances the response of glioma to chemo- and radiotherapy. PLoS One, 2012. 7(9): p. e44603. PDF

  28. Pfaffenbach, K.T., et al., GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling. J Cell Physiol, 2012. 227(12): p. 3803-11. PDF

  29. Lee, C., L. Raffaghello, and V.D. Longo, Starvation, detoxification, and multidrug resistance in cancer therapy. Drug Resist Updat, 2012. 15(1-2): p. 114-22. PDF

  30. Fontana, L., M. Vinciguerra, and V.D. Longo, Growth factors, nutrient signaling, and cardiovascular aging. Circ Res, 2012. 110(8): p. 1139-50. PDF

  31. Lee, C. and V.D. Longo, Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. Oncogene, 2011. 30(30): p. 3305-16. PDF

  32. Longo, V.D. and L. Fontana, Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol Sci, 2010. 31(2): p. 89-98. PDF

  33. Lee, C., et al., Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res, 2010. 70(4): p. 1564-72. PDF

  34. Blagosklonny, M.V., et al., Impact papers on aging in 2009. Aging (Albany NY), 2010. 2(3): p. 111-21. PDF

  35. Safdie, F.M., et al., Fasting and cancer treatment in humans: A case series report. Aging (Albany NY), 2009. 1(12): p. 988-1007. PDF

  36. Raffaghello, L., et al., Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci U S A, 2008. 105(24): p. 8215-20. PDF

  37. Madia, F., et al., Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. J Cell Biol, 2008. 180(1): p. 67-81. PDF

  38. Longo, V.D., M.R. Lieber, and J. Vijg, Turning anti-ageing genes against cancer. Nat Rev Mol Cell Biol, 2008. 9(11): p. 903-10. PDF

 
 
Cardiovascular Diseases​
  1. Brandhorst, S., Longo, VD. Dietary Restrictions and Nutrition in the Prevention and Treatment of Cardiovascular Disease. Circ Res. 2019 Mar 15;124(6):952-965.  

  2. Song, M., et al., Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality. JAMA Intern Med, 2016. 176(10): p. 1453-1463. PDF

  3. Mirzaei, H., S. Di Biase, and V.D. Longo, Dietary Interventions, Cardiovascular Aging, and Disease: Animal Models and Human Studies. Circ Res, 2016. 118(10): p. 1612-25. PDF

  4. Brandhorst, S., et al., A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab, 2015. 22(1): p. 86-99. PDF

  5. Fontana, L., M. Vinciguerra, and V.D. Longo, Growth factors, nutrient signaling, and cardiovascular aging. Circ Res, 2012. 110(8): p. 1139-50. PDF

 
 
Diabetes and Obesity
  1. Hine, C., et al., Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab, 2017. 25(6): p. 1320-1333 e5. PDF

  2. Cheng, C.W., et al., Fasting-Mimicking Diet Promotes Ngn3-Driven beta-Cell Regeneration to Reverse Diabetes. Cell, 2017.  PDF168(5): p. 775-788 e12. PDF

  3. Longo, V.D., et al., Interventions to Slow Aging in Humans: Are We Ready? Aging Cell, 2015. 14(4): p. 497-510. PDF

  4. Levine, M.E., et al., Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab, 2014. 19(3): p. 407-17. PDF

  5. Bartke, A., L.Y. Sun, and V. Longo, Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiol Rev, 2013. 93(2): p. 571-98. PDF

  6. Fontana, L., M. Vinciguerra, and V.D. Longo, Growth factors, nutrient signaling, and cardiovascular aging. Circ Res, 2012. 110(8): p. 1139-50. PDF

  7. Guevara-Aguirre, J., et al., Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med, 2011. 3(70): p. 70ra13. PDF

  8. Fontana, L., L. Partridge, and V.D. Longo, Extending healthy life span--from yeast to humans. Science, 2010. 328(5976): p. 321-6. PDF

  9. Longo, V.D. and B.K. Kennedy, Sirtuins in aging and age-related disease. Cell, 2006. 126(2): p. 257-68. PDF

 
 
​Longevity and Aging
  1. Wei, M., et al., Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med, 2017. 9(377). PDF

  2. Nashiro, K., et al., Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans. J Neurosci, 2017. 37(7): p. 1696-1707. PDF

  3. Lee, A.S., et al., Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Sci Rep, 2017. 7: p. 40919. PDF

  4. Hine, C., et al., Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab, 2017. 25(6): p. 1320-1333 e5. PDF

  5. Choi, I.Y., C. Lee, and V.D. Longo, Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence. Mol Cell Endocrinol, 2017. PDF

  6. Cheng, C.W., et al., Fasting-Mimicking Diet Promotes Ngn3-Driven beta-Cell Regeneration to Reverse Diabetes. Cell, 2017. 168(5): p. 775-788 e12. PDF

  7. Brandhorst, S., et al., Protective effects of short-term dietary restriction in surgical stress and chemotherapy. Ageing Res Rev, 2017. PDF

  8. Vernieri, C., et al., Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions. Cancer Discov, 2016. 6(12): p. 1315-1333. PDF

  9. Song, M., et al., Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality. JAMA Intern Med, 2016. 176(10): p. 1453-1463. PDF

  10. Mirzaei, H., S. Di Biase, and V.D. Longo, Dietary Interventions, Cardiovascular Aging, and Disease: Animal Models and Human Studies. Circ Res, 2016. 118(10): p. 1612-25. PDF

  11. Mattson, M.P., V.D. Longo, and M. Harvie, Impact of intermittent fasting on health and disease processes. Ageing Res Rev, 2016. PDF

  12. Longo, V.D. and S. Panda, Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. Cell Metab, 2016. 23(6): p. 1048-59. PDF

  13. Longo, V.D. and S. Cortellino, Enhancing Stem Cell Transplantation with "Nutri-technology". Cell Stem Cell, 2016. 19(6): p. 681-682. PDF

  14. Dorff, T.B., et al., Safety and feasibility of fasting in combination with platinum-based chemotherapy. BMC Cancer, 2016. 16(1): p. 360. PDF

  15. Di Biase, S. and V.D. Longo, Fasting-induced differential stress sensitization in cancer treatment. Mol Cell Oncol, 2016. 3(3): p. e1117701. PDF

  16. Di Biase, S., et al., Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity. Cancer Cell, 2016. 30(1): p. 136-46. PDF

  17. Choi, I.Y., et al., A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Rep, 2016. 15(10): p. 2136-46. PDF

  18. Brandhorst, S. and V.D. Longo, Fasting and Caloric Restriction in Cancer Prevention and Treatment. Recent Results Cancer Res, 2016. 207: p. 241-66. PDF

  19. Shim, H.S., et al., Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. Cancer Res, 2015. 75(6): p. 1056-67. PDF

  20. Shim, H.S. and V.D. Longo, A protein restriction-dependent sulfur code for longevity. Cell, 2015. 160(1-2): p. 15-7. PDF

  21. Longo, V.D., et al., Interventions to Slow Aging in Humans: Are We Ready? Aging Cell, 2015. 14(4): p. 497-510. PDF

  22. Guevara-Aguirre, J., et al., GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity. J Clin Endocrinol Metab, 2015. 100(7): p. 2589-96. PDF

  23. Caffa, I., V.D. Longo, and A. Nencioni, Fasting plus tyrosine kinase inhibitors in cancer. Aging (Albany NY), 2015. 7(12): p. 1026-7. PDF

  24. Mercken, E.M., et al., SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice. Aging Cell, 2014. 13(1): p. 193-6. PDF

  25. Mattson, M.P., et al., Meal frequency and timing in health and disease. Proc Natl Acad Sci U S A, 2014. 111(47): p. 16647-53. PDF

  26. Longo, V.D. and M.P. Mattson, Fasting: molecular mechanisms and clinical applications. Cell Metab, 2014. 19(2): p. 181-92. PDF

  27. Levine, M.E., et al., Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab, 2014. 19(3): p. 407-17. PDF

  28. Hu, J., et al., Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity. Aging Cell, 2014. 13(3): p. 457-67. PDF

  29. Cheng, C.W., et al., Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell, 2014. 14(6): p. 810-23. PDF

  30. Parrella, E., et al., Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell, 2013. 12(2): p. 257-68. PDF

  31. Safdie, F., et al., Fasting enhances the response of glioma to chemo- and radiotherapy. PLoS One, 2012. 7(9): p. e44603. PDF

  32. Ge, H., et al., Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant. Nucleic Acids Res, 2010. 38(1): p. 143-58. PDF

  33. Finch, C.E., et al., Cell resilience in species life spans: a link to inflammation? Aging Cell, 2010. 9(4): p. 519-26. PDF

  34. Blagosklonny, M.V., et al., Impact papers on aging in 2009. Aging (Albany NY), 2010. 2(3): p. 111-21. PDF

  35. Madia, F., et al., Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. J Cell Biol, 2008. 180(1): p. 67-81. PDF

 
 
Neurodegenerative Diseases
  1. Nashiro, K., et al., Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans. J Neurosci, 2017. 37(7): p. 1696-1707. PDF

  2. Di Biase, S., et al., Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. PLoS Biol, 2017. 15(3): p. e2001951. PDF

  3. Mattson, M.P., et al., Meal frequency and timing in health and disease. Proc Natl Acad Sci U S A, 2014. 111(47): p. 16647-53. PDF

  4. Parrella, E., et al., Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell, 2013. 12(2): p. 257-68. PDF

  5. Safdie, F., et al., Fasting enhances the response of glioma to chemo- and radiotherapy. PLoS One, 2012. 7(9): p. e44603. PDF

  6. Parrella, E. and V.D. Longo, Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. ScientificWorldJournal, 2010. 10: p. 161-77. PDF

  7. Michan, S., et al., SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci, 2010. 30(29): p. 9695-707. PDF

  8. Raffaghello, L., et al., Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci U S A, 2008. 105(24): p. 8215-20. PDF

  9. Li, Y., et al., SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab, 2008. 8(1): p. 38-48. PDF

  10. Longo, V.D. and B.K. Kennedy, Sirtuins in aging and age-related disease. Cell, 2006. 126(2): p. 257-68. PDF

  11. Longo, V.D. and C.E. Finch, Genetics of aging and diseases: from rare mutations and model systems to disease prevention. Arch Neurol, 2002. 59(11): p. 1706-8. PDF

  12. Finch, C.E., et al., Inflammatory mechanisms in Alzheimer Disease, and Aging, in Molecular Mechanisms in Neurodegenerative Diseases, M.F. Chesselet, Editor. 1999, Humana Press: Totowa, NJ. PDF