We have brought together biogerontology laboratories from the University of Southern California and Harvard University to study the molecular mechanisms linking fasting, fasting-mimicking diets and protein restriction to growth genes, the stress resistance signaling network, mitochondrial biology, cellular protection, regeneration, and aging. These studies will contribute to the identification of drugs and interventions to treat and prevent multiple diseases by acting on the aging process and on multi-system regeneration and rejuvenation.